Effect of a diet rich in sunflower oil on aspects of lipid metabolism in the genetically-obese rat |
| |
Authors: | Wahle K W J Radcliffe J D |
| |
Affiliation: | (1) Rowett Research Institute, Bucksburn, AB2 9SB Aberdeen, UK |
| |
Abstract: | Aspects of the lipid metabolism of male, obese and lean Zucker rats were compared using animals which had been fed ad libitum
for 32 days on a diet (HS) which contained 200 g sunflowerseed oil/kg or one (LS) which contained 50 g/kg of the oil. When
compared with the LS diet, the HS diet decreased the characteristic lipid accretion in the liver of obese rats from 126 mg
(LS) to 81 mg (HS)/g wet weight; corresponding values for the lean rats were 39 mg and 56 mg/g wet weight of liver, respectively.
The HS diet depressed lipid synthesis de novo by liver homogenates and decreased the Δ9-desaturase activity of liver microsomes
from obese and clean rats by about 50%. Δ9-Desaturase activity in vitro was also depressed by the addition of linoleic acid
to liver microsomes from both obese and lean rats fed ad libitum on a standard laboratory diet. Depressed Δ9-desaturase activity,
due to ingestion of the HS diet, was reflected in lower ratios of 16∶1/16∶0 and 18∶1/18∶0 fatty acids in tissue lipids from
obese and lean rats. Ingestion of the HS compared with the LS diet resulted in increased proportions of 18∶2ω6 in liver lipids
and adipose tissue triacylglycerols of obese and lean rats. The HS diet also increased the proportions of 20∶4ω6 in adipose
triacylglycerols of obese and lean rats and in liver lipids of obese animals but not in their lean littermates. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|