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Reduction‐Responsive Guanine Incorporated into G‐Quadruplex‐Forming DNA |
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| Authors: | Prof. Masato Ikeda Masahiro Kamimura Yukiko Hayakawa Dr. Aya Shibata Prof. Yukio Kitade |
| Affiliation: | 1. Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1, Gifu, Japan;2. Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1, Gifu, Japan;3. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1, Gifu, Japan |
| Abstract: | Stimulus‐responsive biomolecules are attractive targets to understand biomolecule behaviour as well as to explore their therapeutic and diagnostic applications. We demonstrate that a reduction‐responsive cleavable group (chemically caged unit) introduced into the guanine ring enables modulation of the secondary structure transition of an oligonucleotide in a reduction‐responsive and traceless manner leaving the unmodified oligonucleotide of interest. This simple but robust strategy could yield a variety of stimuli‐responsive oligonucleotides. |
| Keywords: | cleavage reactions conjugation DNA structures G-quadruplexes stimuli-responsive |