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Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G‐Quadruplex in the Solid State |
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| Authors: | Dr Pradeep K Mandal Dr Benoît Baptiste Dr Béatrice Langlois?d'Estaintot Dr Brice Kauffmann Dr Ivan Huc |
| Affiliation: | 1. University of Bordeaux, CBMN, UMR 5248), Institut Européen de Chimie et Biologie, Pessac, France;2. CNRS, CBMN, UMR 5248), Pessac, France;3. Bordeaux Institut National Polytechnique, CBMN, UMR 5248), Pessac, France;4. University of Bordeaux, IECB, UMS 3033), Institut Européen de Chimie et Biologie, Pessac, France;5. CNRS, IECB, UMS 3033), Pessac, France;6. INSERM, IECB, US001), Pessac, France |
| Abstract: | Quinoline‐based oligoamide foldamers have been identified as a potent class of ligands for G‐quadruplex DNA. Their helical structure is thought to target G‐quadruplex loops or grooves and not G‐tetrads. We report a co‐crystal structure of the antiparallel hairpin dimeric DNA G‐quadruplex (G4T4G4)2 with tetramer 1 —a helically folded oligo‐quinolinecarboxamide bearing cationic side chains—that is consistent with this hypothesis. Multivalent foldamer–DNA interactions that modify the packing of (G4T4G4)2 in the solid state are observed. |
| Keywords: | DNA ligands DNA structures foldamers G-quadruplexes solid-state interactions |