Occurrence of diabetes, hyperinsulinism and other risk factors for atherosclerosis in patients with pernicious anemia] |
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Authors: | P Kessler J Veberová I Bradácková |
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Affiliation: | Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague. |
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Abstract: | The anticonvulsant action of felbamate (25, 50, 100 and 150 mg/kg i.p.) was tested against motor seizures induced by pentylenetetrazol in five age-groups of rats (7, 12, 18, 25 and 90 days old). In adult rats, felbamate suppressed generalized tonic-clonic seizures leaving intact minimal clonic seizures. In all groups of rat pups felbamate exhibited a specific action against the tonic phase of generalized tonic-clonic seizures. In addition, the highest dose of felbamate was found to suppress minimal seizures in 18-day-old rats. The changes of felbamate action during ontogeny might be due to multiple mechanisms of anticonvulsant action with an uneven developmental profile. |
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