Optimization of supercritical CO2 extraction of different anatomical parts of lovage (Levisticum officinale Koch.) using response surface methodology and evaluation of extracts composition |
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| Affiliation: | 1. Postgraduate Program in Health Science, State University of Maringa, Parana, Brazil;2. Laboratory of Medical Bacteriology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Parana, Brazil;3. Department of Basic Health Sciences, State University of Maringa, Parana, Brazil;1. Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovi?a 12, 34000 Kragujevac, Serbia;2. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovi?a 69, 34000 Kragujevac, Serbia;3. Institute for Biological Research “Sini?a Stankovi?”, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia;4. Institute of Pathology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovi?a 69, 34000 Kragujevac, Serbia;5. Department of Histology and Embryology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovi?a 69, 34000 Kragujevac, Serbia;1. Research Center for Biomolecules, Universidad Industrial de Santander, Bucaramanga, Colombia;2. Departamento de Ingeniería Química y Bioprocesos, Pontificia Universidad Católica de Chile, Santiago, Chile;3. Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Centro de Biotecnología FEMSA, Mexico;4. Departamento de Ingeniería Química y Ambiental, Universidad Técnica Federico Santa María, Santiago, Chile |
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| Abstract: | Supercritical carbon dioxide extraction (SFE-CO2) parameters were optimized using response surface methodology and central composite design for lovage (Levisticum officinale Koch.) roots and leaves containing valuable phytoconstituents. Mathematical model predicted the highest yields of extracts from roots and leaves 2.26 and 2.29%, respectively, at 45 MPa pressure, 60 °C temperature, 90 min (roots) and 30 min (leaves) extraction time, whereas the yield of hydrodistilled essential oil was 0.24 and 0.74%, respectively. The highest relative content of the most valuable constituent Z-ligustilide in roots and leaves extracts was 77 and 50% at 10 MPa; however, the highest yields of this compound from 100 g of dry material were obtained at the highest applied pressure and constituted 1188 mg (roots) and 540 mg (leaves). This study showed that lovage is a good source of Z-ligustilide and SFE-CO2 is a preferable technique for its isolation. |
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| Keywords: | Supercritical carbon dioxide extraction Response surface methodology |
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