Phase equilibrium data of guaçatonga (Casearia sylvestris) extract + ethanol + CO2 system and encapsulation using a supercritical anti-solvent process |
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| Affiliation: | 1. EQA-CTC/UFSC, Chemical and Food Engineering Department, Federal University of Santa Catarina, C.P. 476, CEP 88040-900, Florianópolis, SC, Brazil;2. BQA-CCB/UFSC, Biochemistry Department, Federal University of Santa Catarina, C.P. 476, CEP 88040-900, Florianópolis, SC, Brazil;1. Environmental Sciences Area, Universidade Comunitária da Região de Chapecó (Unochapecó), PO Box 1141, Chapecó, SC, Brazil;2. Department of Chemical and Food Engineering, UFSC, Florianópolis, SC, Brazil;3. Epagri - Research Center for Family Farming, PO Box 791, Chapecó, SC 89801-970, Brazil;1. Department of Biotechnology, Delft University of Technology, Leeghwaterstraat 44, 2628 CA Delft, The Netherlands;2. Engineering of Fibrous Smart Materials, University of Twente, Buitenhorst 217, 7522 LW Enschede, The Netherlands;3. Fraunhofer Institute for Production Systems and Design Technology Pascalstrasse 8-9, 10587 Berlin, Germany;4. FeyeCon Carbon Dioxide Technologies Rijnkade 17a, 1382GS Weesp, The Netherlands;5. Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, the Netherlands;1. Faculty of Food Engineering, Federal University of Pará, Rua Augusto Corrêa S/N, Guamá, 66075-900 Belém, Pará, Brazil;2. Faculty of Chemical Engineering, Federal University of Pará, Rua Augusto Corrêa S/N, Guamá, 66075-900 Belém, Pará, Brazil;3. Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Biological Sciences, Federal University of Pará, Rua Augusto Corrêa S/N, Guamá, 66075-900 Belém, PA, Brazil;4. Faculty of Sciences and Technology, Federal University of Pará, Rua Manoel de Abreu S/N, Multirão, 68440-000 Abaetetuba, Pará, Brazil;1. LASEFI/DEA/FEA (School of Food Engineering)/UNICAMP (University of Campinas), Rua Monteiro Lobato, 80, Campinas, SP CEP: 13083-862, Brazil;2. DE/IMECC (Department of Statistics), UNICAMP (University of Campinas), Rua Sérgio Buarque de Holanda, Campinas, SP 13081-970, Brazil |
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| Abstract: | The aim of this research was to investigate the phase equilibrium behavior of a system containing guaçatonga extract + ethanol + CO2 in order to help define the adequate conditions of temperature and pressure for the co-precipitation process, performed by means of supercritical anti-solvent (SAS) technique. Guaçatonga (Casearia sylvestris) is a native medicinal plant from Brazil, rich in valuable components such as β-caryophyllene, α-humulene and bicyclogermacrene. Phase equilibrium data were obtained by the static method using guaçatonga extract dissolved in ethanol (1:100, wt/wt), at temperatures ranging from 35 to 75 °C and CO2 mass content from 60 to 90 wt%. It was noticed that the system exhibited solid–vapor–liquid, solid–liquid–liquid and solid–vapor–liquid–liquid transition types and a lower critical solution temperature behavior. Phase behavior study was considered for the definition of the SAS conditions applied for the encapsulation of guaçatonga extract in the biopolymer Pluronic F127. The conditions tested ranged from 80 to 140 bar at 45 °C. At 80 bar only segregated particles of extract and the biopolymer were detected, while at 110 and 140 bar an extract encapsulation was achieved. |
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| Keywords: | Phase behavior Particle formation SAS Medicinal plant |
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