Biomarkers for Cancer Cachexia: A Mini Review |
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| Authors: | Zhipeng Cao Kening Zhao Irvin Jose Nick J Hoogenraad Laura D Osellame |
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| Affiliation: | 1.Department of Biochemistry and Genetics, La Trobe University, Bundoora, VIC 3086, Australia; (K.Z.); (I.J.); (N.J.H.);2.Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;3.Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Melbourne, VIC 3084, Australia |
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| Abstract: | Cancer cachexia is a common condition in many cancer patients, particularly those with advanced disease. Cancer cachexia patients are generally less tolerant to chemotherapies and radiotherapies, largely limiting their treatment options. While the search for treatments of this condition are ongoing, standards for the efficacy of treatments have yet to be developed. Current diagnostic criteria for cancer cachexia are primarily based on loss of body mass and muscle function. However, these criteria are rather limiting, and in time, when weight loss is noticeable, it may be too late for treatment. Consequently, biomarkers for cancer cachexia would be valuable adjuncts to current diagnostic criteria, and for assessing potential treatments. Using high throughput methods such as “omics approaches”, a plethora of potential biomarkers have been identified. This article reviews and summarizes current studies of biomarkers for cancer cachexia. |
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| Keywords: | cancer cachexia biomarkers cachexia-inducing factors |
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