Phosphorylcholine end‐capped poly‐ε‐caprolactone: A novel biodegradable material with improved antiadsorption property |
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Authors: | Sheng Meng Wei Zhong Laisheng L Chou Qihong Wang Zongjun Liu Qiangguo Du |
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Affiliation: | 1. Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China;2. Department of Biomaterials, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118;3. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China;4. Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China |
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Abstract: | In this study, the synthesis, characterization, and properties of a novel biodegradable polymer with improved hemocompatibility were introduced. It was synthesized by end‐capping poly‐ε‐caprolactone (PCL) with phosphorylcholine (PC) groups. The polyester backbone provided the mechanical stability and biodegradability, while the PC‐end groups improved its hemocompatibility. The obtained polymer was characterized using 1H NMR, 31P NMR, FTIR, and GPC, its crystallization behavior was studied by DSC. Compared with original PCL, the resulting polymer (PC‐PCL) showed a lower crystallization capability and a faster degradation rate in PBS. The degradation rate of the polymer blends of PCL/PC‐PCL increased with increasing PC‐PCL content. The results of water contact angle measurements revealed a more hydrophilic surface property of PC‐PCL than neat PCL. The hemocompatibility of PC‐PCL was estimated using rabbit platelet‐rich plasma, a better resistance to platelet adhesion and activation was observed. During the human blood plasma contacting process, PC‐PCL showed a prolonged activated partial thromboplastin time over neat PCL. Material–cell interaction was evaluated with human umbilical vein endothelial cell, the result indicated that PC‐PCL may to some extent have an antihyperplasia property, compared with neat PCL. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 989–997, 2007 |
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Keywords: | phospholipids polyesters biodegradable biocompatibility |
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