Synthesis of monomethoxy poly(ethylene glycol) without diol poly(ethylene glycol) |
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| Authors: | Jing Zhang Yong‐Jiang Zhao Zhi‐Guo Su Guang‐Hui Ma |
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| Affiliation: | 1. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academic of Sciences, Beijing 100080, People's Republic of China;2. Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
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| Abstract: | Since monomethoxy poly(ethylene glycol) (mPEG) inevitably contains diol PEG and is difficult to get high molecular weight through traditional synthesis at high temperature under high pressure, a novel synthetic technique via anionic solution polymerization was reported in this study. With a new initiating system, potassium naphthalene and methanol, was introduced, the polymerization proceeded at ambient temperature and side reactions were well restrained. Furthermore, a slight excess of potassium naphthalene can effectively remove the trace of water and oxygen in the reaction system. Under this condition, mPEG was nearly quantitatively obtained without containing diol PEG. Its Mn ranged from 1 to 30 kDa and the polydispersity was kept lower than 1.07. Characterization of the mPEG obtained was carried out using GPC to determine the content of diol PEG and 1H‐NMR and MALDI‐ToF MS spectroscopic analysis to confirm the exact structure. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007 |
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| Keywords: | anionic polymerization ring‐opening polymerization polyethers high molecular weight high purity |
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