pH‐sensitive alginate/soy protein microspheres as drug transporter |
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Authors: | Hua Zheng Ziyan Zhou Yun Chen Jin Huang Fuliang Xiong |
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Affiliation: | 1. College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China;2. Research Center for Medicine and Structural Biology, School of Medicine, Wuhan University, Wuhan 430072, China;3. Key Laboratory of Cellulose and Lignocellulosics Chemistry, Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650, China |
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Abstract: | The complex microspheres based on alginate (AL) and soy protein isolate (SPI) were prepared by solution blending and then Ca2+ crosslinking, and their function as drug carrier was explored as well. The effects of composition on the structures of microspheres were studied, and the XRD results proved the miscibility between components. Meanwhile, FTIR results suggested that such miscibility was driven by strong hydrogen bonding. Especially, the complex microsphere with equal content of AL and SPI had the best miscibility by morphological analysis, shown as a smooth and uniform surface of SEM images. The controlled release function of the complex microspheres was verified using theophylline as a drug model, that is, the swelling and drug release were affected by pH conditions and showed obvious differences under given pH of stomach, intestine, and colon. Moreover, the intestine and colon may be optimal site for prompt release of drugs. Except for the attribution of AL component to pH sensitivity, the complex microspheres also inherited the bioactivity of SPI component, which may lower irritants of drug to the tissues in body. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007 |
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Keywords: | soy protein alginate microsphere blend drug‐delivery system |
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