| 18F-FBEM-NGA的合成及结构表征 |
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| 引用本文： | 彭程,景慧慧,牟甜甜,杨文江,马云川,张现忠.18F-FBEM-NGA的合成及结构表征[J].同位素,2011,24(2):83-88. |
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| 作者姓名： | 彭程 景慧慧 牟甜甜 杨文江 马云川 张现忠 |
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| 作者单位： | 1．首都医科大学 宣武医院 PET中心，北京100053；2. 放射性药物教育部重点实验室， 北京师范大学 化学学院，北京100875 |
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| 基金项目： | 国家自然科学基金资助项目，北京市自然科学基金资助项目 |
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| 摘 要： | 以F-FBEM对新乳糖白蛋白(NGA)进行标记,探讨标记辅助基团标记蛋白或多肽的可行性.用18F-SFB与N-(2-氨基乙基)马来酰亚胺三氟乙酸盐反应合成了一种用于正电子发射计算机断层显像(PET)药物的辅助基团18F-FBEM,并进一步制得18F-FBEM-NGA.18F-FBEM的标记时间为2.5 h,经衰变校正后...
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| 关 键 词： | 18F 18F-FBEM 18-FBEM-NGA 结构表征 |
Synthesis and Characterization of 18F-FBEM-NGA as a Potential ASGP Receptor Imaging Agent |
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| PENG Cheng,JING Hui-hui,MOU Tian-tian,YANG Wen-jiang,MA Yun-chuan,ZHANG Xian-zhong.Synthesis and Characterization of 18F-FBEM-NGA as a Potential ASGP Receptor Imaging Agent[J].Isotopes,2011,24(2):83-88. |
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| Authors: | PENG Cheng JING Hui-hui MOU Tian-tian YANG Wen-jiang MA Yun-chuan ZHANG Xian-zhong |
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| Affiliation: | 1．PET Center of Xuanwu Hospital, Capital Medical University, Beijing 100053, China; 2．Key Laboratory of Radiopharmaceuticals, Ministry of Education,College of Chemistry, Bejing Normal University, Beijing 100875, China |
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| Abstract: | A 18F-labelling prosthetic group named as N-2-(4-18F-fluorobenzamido) ethyl] maleimide(18F-FBEM) was prepared for peptides and protein labeling,and the radiopharmaceuticals prepared from this prosthetic group were designed for positron emission tomography(PET) imaging.This prosthetic group was synthesized by the reaction of N-succinimidyl 4-18F-fluorobenzoate(18F-SFB) with N-(2-aminoethyl) maleimide trifluoroacetate salt.The total synthesis time from 18F-to 18F-FBEM was about 2.5 h with decay corrected rad... |
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| Keywords: | 18F 18F-FBEM 18F-FBEM-NGA characterization |
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