基于细胞沉积的人工骨微管设计及三维流场分析

针对人工骨微管中细胞均匀粘附和营养成分顺利运输所需流速条件,研究支管与主管道之间的夹角对支管中流速的影响以及沿主管道不同位置的支管中液体速度分布,并结合自然骨微观结构以及流体力学中的能量守恒和流量守恒原理,提出一种强化微循环结构并进行三维粘性流场数值分析,将分析结果与单纯仿形结构的流场分析结果比较,结果表明,该结构流速分布更均匀,支管内流速得到很大程度的提高,有利于细胞均匀粘附和进一步提高人工骨设计孔隙率。

BIONIC DESIGN AND 3D FLOW ANALYSIS OF ARTIFICIAL BONE MICROTUBULES AND FABRICATION BASED ON CELL ATTACHMENT

To obtain the velocity of flow field for cell attached uniformly and for nutrients supplied successfully, effect of the various angles between main channel and branching channels and of the location of the branching channels along the main channel on velocity of flow in branching channels is studied by numerical analysis. And a new ductwork design is presented based on microstructure of natural bone and conversation of energy and flux. The 3D viscous computational fluid dynamics (CFD) analysis is carried out on it. The 3D flow simulation results are compared with that of ordinary structure. The conclusion shows that such a 3D flow channel arrangement produces higher velocity and more uniform distribution of velocity in branching channels. That is to say, cell attachment is more uniform and making the number of branching channels increased is possible.