Versatile hybrid polyethyleneimine–mesoporous carbon nanoparticles for targeted delivery |
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| Affiliation: | 1. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China;2. Shenyang Sunshine Pharmaceutical CO., LTD, 3 A1, Road 10, Shenyang Economy & Technology Development Zone, Shenyang 110027, PR China;3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China;1. Adam Mickiewicz University in Poznań, Poznań, Poland;2. University of Coimbra, Coimbra, Portugal;3. University of Trás-os-Montes and Alto Douro, Vila Real, Portugal;1. Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China;2. School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China;1. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran;2. Department of Chemistry, Faculty of Science, Golestan University, Gorgan, Iran;3. Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;4. Department of Environmental Health Engineering, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran;5. Department of Emergency Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;6. Department of Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran;1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China;2. State Key Laboratory of Subtropical Building Science, South China University of Technology, Guangzhou, 510640, China;1. Department of Nephrology, Huadu District People''s Hospital of Guangzhou, Southern Medical University, Guangzhou, 510800, China;2. Department of Nephrology, Affiliated Hospital of Taishan Medical University, Taian, 271000, China;3. Department of Gastroenterology, Huadu District People''s Hospital of Guangzhou, Southern Medical University, Guangzhou, 510800, China;4. Department of Nephrology, Tai''an City Central Hospital, Taian, 271000, China |
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| Abstract: | To meet the needs of targeted drug delivery and medical imaging, uniform mesoporous carbon spheres (UMCS) were functionalized using hyperbranched polyethyleneimine (PEI) covalently linked with fluorescein isothiocyanate (FITC) and folic acid (FA). Folate-receptor-positive KB cancer cells internalized five times more nanoparticles than A549 cells deficient in folate receptors in vitro using flow cytometry and confocal microscopy. The in vivo distribution results also confirmed that the FA–PEI–FITC–UMCS nanoparticles could target the FA-positive tumors. In addition, the specifically targeted hybrid carbon nanoparticles exhibited non-cytotoxic and controlled intracellular release (pH dependent) of the loaded agents. The in vivo antitumor effect of the paclitaxel (PTX)-loaded nanoparticles was investigated in Kunming mice harboring a hepatic H22 tumor. PTX-loaded FA–PEI–UMCS nanoparticles displayed superior antitumor effects compared to other PTX formulations, and the tumor growth inhibition rate was 86.53% compared with the control group (saline) for the enhanced targeted accumulation of NPs in tumor cells. |
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