Synthesis, cytotoxicity and SAR of simple geiparvarin analogues |
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Authors: | P Valenti A Rampa M Recanatini A Bisi F Belluti P Da Re M Carrara L Cima |
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Affiliation: | Department of Pharmaceutical Sciences, University of Bologna, Italy. |
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Abstract: | Some simple geiparvarin analogues, in which the coumarin moiety has been replaced with an X-substituted benzene ring, are described. The compounds were tested on LoVo cells (human colon carcinoma cell line) and some of them show a cytotoxicity comparable with that of the prototype. A QSAR analysis was also attempted, but it did not provide satisfactory results, mainly because of the limited range of variation of the biological activity. |
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