Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes |
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| Affiliation: | 1. Departamento de Química Inorgánica y Analítica, E.S.C.E.T., Universidad Rey Juan Carlos, 28933 Móstoles, Madrid, Spain;2. Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, Studentski trg 14, 11000 Belgrade, Serbia;3. Institute of Oncology and Radiology, 11000 Belgrade, Serbia;4. Faculty of Chemistry, University of Belgrade, P.O. Box 158, 11001 Belgrade, Serbia;1. Inorganic & Nanomaterials Research Laboratory, Department of Chemistry, Bharathiar University, Coimbatore 641 046, India;2. Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA;1. Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary;2. Institute of Chemistry, Laboratory for X-ray Diffraction, University of Debrecen, Egyetem tér 1, Debrecen H-4032, Hungary;3. HAS-USZ Bioinorganic Chemistry Research Group, Dóm tér 7, H-6720 Szeged, Hungary;1. School of Advanced Sciences, VIT University, Vellore 632014, Tamilnadu, India;2. BIF, School of Life Sciences, University of Hyderabad, Hyderabad 500046, Telangana, India;1. Dipartimento STEBICEF, Parco d’Orleans II, Viale delle Scienze – Ed. 16, 90128 Palermo, Italy;2. Dipartimento di Chimica G. Ciamician, Università di Bologna, via F. Selmi 2, 40126 Bologna, Italy |
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| Abstract: | The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me(CH2 CH)Si(η5-5Me4) (η5-C5H4)}Cl2] (1), [Ti{Me(H)Si(η5-C5Me4)2}Cl2] (2), [Ti{Me{(CH2CH)Me2SiCH2CH2}Si(η5-C5Me4)(η5-C5H4)}Cl2] (3) and [Ti{Me2Si(η5-C5Me4)(η5-C5H3(CMe2(CH2CH2CHCH2)))}Cl2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. |
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