Functionalised supports with sugar dendritic ligand |
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| Affiliation: | 1. Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology, Beijing 100029, PR China;2. Chembiotech Laboratories, University of Birmingham Research Park, Vincent Drive, Birmingham B15 2SQ, UK;1. Nanobiotechnology for Diagnostics (Nb4D), IQAC-CSIC, Jordi Girona, 18-26, 08034 Barcelona, Spain;2. Combinatorial Chemistry Unit, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain;3. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain;4. Department of Organic Chemistry, University of Barcelona, 080028 Barcelona, Spain;5. School of Chemistry, University of Kwa-Zulu-Natal, 4001 Durban, South Africa;1. Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Carrer Marcel·lí Domingo s/n, Campus Sescelades, 43007 Tarragona, Spain;2. Departament d’Enginyeria Química, Universitat Rovira i Virgili, Av. Països Catalans, 26, Campus Sescelades, 43007 Tarragona, Spain;3. Institute for Polymers, Composites and Biomaterials, via Campi Flegrei, 34, 80078 Pozzuoli, Napoli, Italy;4. Leibniz-Institute of Polymer Research Dresden, Hohe Str. 6, 01069 Dresden, Germany;1. Chair of Materials Science, Department of Materials Science and Technology, Otto Schott Institute of Materials Research, Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Löbdergraben 32, 07743 Jena, Germany;2. Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA;3. Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany |
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| Abstract: | Functionalised supports with sugar dendritic ligand were obtained from chemical modification on poly(hydroxylated polybutadienic-hydroxyethyl methacrylate) [poly(PB-HEMA)] matrix. The matrix was activated with 1,4 butanediol diglycidyl ether (BDGE) or epichlorohydrin (ECH). Later, a dendritic molecule was immobilised and submitted to react with glucose (GLU) using a carbodiimide reagent. Then, glucose-containing supports were used as sorbents to retain Concanavalin A (Con A).Properties such as equilibrium volume swelling ratios (qv), extent of conversion of functional groups, amount of bound dendritic molecule and amount of coupled glucose were analysed. |
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