Preparation of biomimetic three-dimensional gelatin/montmorillonite–chitosan scaffold for tissue engineering |
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| Affiliation: | 1. Department of Bioengineering, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China;2. Light Alloy Corrosion Laboratory, College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China;3. Hospital of Shandong University of Science and Technology, Qingdao 266590, China;4. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450002, China;1. Biomaterials Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Tehran, Iran;2. Orthopedic Research Center, Qhaem Hospital Medical School, Mashhad University of Medical Sciences, Mashhad, Iran;3. Composites Department, Iran Polymer and Petrochemical Institute, Tehran, Iran |
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| Abstract: | A novel gelatin/montmorillonite–chitosan (Gel/MMT–CS) nanocomposite scaffold was prepared via the intercalation process and the freeze-drying technique, using the ice particulates as the porogen materials. Properties including pore structure, water adsorption content, in vitro degradation and tensile strength were investigated. It was demonstrated that the introduced intercalation structure endowed the Gel/MMT–CS scaffold with good mechanical properties and a controllable degradation rate. Scanning of the electron microscope images revealed that the scaffold obtained was highly porous and suitable for the implanted cells to adhere and grow. The mitochondrial activity assay provided good evidences of cells viability on the Gel/MMT–CS membranes, giving an indication of possible application as a matrix for tissue engineering. |
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