Synthesis,crystal structure and urease inhibitory activities of Schiff base metal complexes |
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| Affiliation: | 1. Department of Medical Laboratory, Vocational School of Health Services, Selcuk University, Campus, 42075, Konya, Turkey;2. Department of Chemistry, Selcuk University, Campus, 42075, Konya, Turkey;1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt;2. Drinking Water and Sanitation Company, Mansoura, Egypt;1. Department of Chemistry, University of Zabol, Zabol, Iran;2. Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran;3. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran;1. Department of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation;2. Department of Chemistry, State Pedagogical University “A.I. Herzen”, St. Petersburg, Russian Federation;3. Kunming University of Science and Technology, Kunming, China;4. Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russian Federation |
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| Abstract: | Six new transition metal complexes (1–6) with Schiff base were synthesized and crystallographically characterized. Their urease inhibitory activities were evaluated. Three of them showed potent inhibitions against jack bean urease. Mn(II) complex (2) possessed the best jbU inhibitory activity with IC50 of 8.30 ± 0.93 μM, which was much better than those of the corresponding ligand and control ion. The investigation on the stability constants and the structure-activity relationships of the complexes indicated that the complexes interacted with the enzyme in the whole complex forms rather than the free ions. |
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