Multiscale modeling in rodent ventricular myocytes |
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Authors: | Shaoying Lu Michailova A. Saucerman J. Yuhui Cheng Zeyun Yu Kaiser T. Li W. Bank R. Holst M. Mccammon J. Hayashi T. Hoshijima M. Arzberger P. McCulloch A. |
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Affiliation: | Dept. of Bioeng., Univ. of California San Diego, La Jolla, CA; |
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Abstract: | This paper indicates that in ventricular myocytes when the SR (sarcoplasmic reticulum) is pharmacologically inhibited, the intracellular Ca2+concentration rapidly increases during Ca2+ entrance (0-70 ms), whereas the decay of Ca2+ is slow; in the absence of fluorescent dye, large Ca2+ concentration gradients might develop near the cell membrane; intracellular Ca2+ distribution is tightly regulated by the localization of Ca2+transporter proteins along the sarcolemma and strongly relays on the presence of mobile and stationary Ca2+ buffers. These studies also imply that in ventricular cells with intact and functional SR, the Ca2+ signal most likely would spread faster along the t-tubular system, surface membrane than to the cell interior and that in the absence of Ca2+ dye high Ca2+ gradients under the surface membrane and more uniform Ca2+ distribution in the cell interior might be expected. |
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