Endocardial fibroelastosis in L-transposition of the great arteries with Ebstein's anomaly: revisited |
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Authors: | NS Dahdah NH van Doesburg P Russo |
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Affiliation: | New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan. |
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Abstract: | An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7-O-TES-10-deacetylbaccatin III and appropriate alkenes. In addition the cytotoxic activity of 10-alkylated docetaxel analogs was evaluated. Among these analogs, a derivative having a methoxycarbonyl group at the end of the alkyl moiety exhibited more potent cytotoxic activity than docetaxel. |
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