细胞尺度10B不均匀分布对细胞微剂量影响的计算与分析

硼中子俘获治疗已经成为当前治疗恶性黑色素瘤、头颈部肿瘤等恶性肿瘤的有效手段之一。¹⁰B在细胞尺度上不均匀分布将直接影响到对肿瘤细胞失活剂量的控制。为研究含硼化合物在细胞内空间上分布不同对靶区细胞微剂量的影响，本工作利用Monte-Carlo工具包开发了用于计算¹⁰B（n，α）⁷Li产生的α与⁷Li对靶区剂量的模拟程序α-Li Version 1.0。通过此程序，计算了2种细胞尺寸、8种α粒子能量、3种源分布方式的细胞S值，并与MIRD委员会解析算法的计算结果进行对比，两者差异在1%以内；对不同细胞核半径、不同细胞半径及不同源位置等条件下的3 420种模型进行了模拟计算，证明了α粒子和⁷Li粒子在细胞内的S值存在差异性；最终获得的¹⁰B（n，α）⁷Li反应的细胞S值数据库，可用于细胞尺度¹⁰B不均匀分布情况下的高精度微剂量学计算。

Analysis of Effect on Microdose of 10B Nonuniform Distribution in Cellular

Boron neutron capture therapy (BNCT) is one of the effective way to treat malignant melanoma and head-neck cancer. The intercellular nonuniform distributions of ¹⁰B in tumor cell impact the estimates of inactivation dose. The α-Li Version 1.0 code was developed based on Monte-Carlo method to calculate the S values of cell induced by αand ⁷Li particle which are the products of  ¹⁰B（n,α）⁷Li. The calculation included two types of cell size, eight kinds of energy of α particle and three kinds of source distributions. Differences between results of this code and an analytical algorithm of MIRD committee were within 1%. On this basis, a total of 3 420 cases were calculated and analyzed with different kinds of nucleus radius, cell radius, and source launch position combination. Finally, cellular S values of ¹⁰B（n,α）⁷Li calculated in this paper can be used to compute the excellent precision dose under ¹⁰B compound nonuniform distribution in intercellular scale.