超临界乳液萃取法制备载槲皮素微胶囊

采用超临界乳液萃取法(SFEE)制得载槲皮素微胶囊,系统考察了制备过程中萃取温度、压力、CO2流速、配制乳液参数对溶剂残留与微胶囊粒径的影响。采用顶空气相色谱法、场发射扫描电镜、Zeta电位、FTIR对溶剂残留与微胶囊进行表征。结果表明:在313 K、9 MPa、CO2流速为0.4 L/min的条件下,处理40 min,溶剂残留可低至59 mg/L。壁材质量浓度从10 g/L增加至100 g/L时,微胶囊粒径由0.9μm升至3.7μm。与溶剂蒸发法相比,SFEE法可在短时间内有效去除有机溶剂,所制备的微胶囊球形度高,界面清晰,在水中稳定性好。

Production of microcapsules loaded with quercetin by supercritical fluid extraction of emulsions

The microcapsules loaded with quercetin were prepared by supercritical fluid extraction of emulsions (SFEE). The influence of process parameters like operating temperature and pressure, CO2 flow rate and emulsion parameters was studied with respect to microcapsules size, distribution and solvent residue. The solvent residue and microcapsules were characterized by headspace gas chromatography, field emission scanning electron microscopy, Zeta potential and Fourier transform infrared spectroscopy. The results showed that the solvent residue can be as low as 59 mg/L after 40 min treatment at 313 K, 9 MPa and CO2 flow rate of 0.4 L/min. When the wall material concentration increases from 25 g/L to 100 g/L, the microcapsules size increased from 0.9 m to 3.7 m. Compared with the solvent evaporation method, the SFEE method can effectively remove the organic solvent in a short time and the analyses confirmed that the prepared microcapsule has high sphericity, clear interface and good stability in water.