| Fe3O4／葡聚糖磁性微球的制备及在药物输运中的潜在应用 |
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| 引用本文： | 姜翠凤,江万权,郝凌云,龚兴龙,曹真,顾瑞.Fe3O4／葡聚糖磁性微球的制备及在药物输运中的潜在应用[J].功能材料,2007,38(A05):1957-1960. |
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| 作者姓名： | 姜翠凤 江万权 郝凌云 龚兴龙 曹真 顾瑞 |
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| 作者单位： | [1]中国科学技术大学化学系,安徽合肥230026 [2]中国科学技术大学力学和机械工程系 中科院材料力学行为与设计重点实验室,安徽合肥230027 [3]阜阳师范学院,安徽阜阳236032 |
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| 基金项目： | 国家自然科学基金资助项目（10672154）：高等学校博士学科点专项科研基金（20050358010） 致谢：感谢中国科学院“百人计划”对本文的支持. |
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| 摘 要： | 首先以单分散性良好的PSA为模板，用还原铁盐方法生成PSA@Fe3O4核壳结构复合微球。再将生成的粒子加入到四氢呋喃（THF）溶剂中，使PSA模板溶解，得到Fe3O4空心微球。在一定条件下将葡聚糖吸附在磁性微球表面，得到吸附有高分子的磁性微球。采用X射线衍射（XRD）、透射电子显微镜（TEM）、傅立叶变换红外光谱（FT-IR）和热重分析（TGA）对制备的微球进行表征。粒子大小均匀，平均直径在50nm左右，Fe3O4层厚约为5nm。这种新颖的磁性高分子微球具有纳米级的尺寸和独特的空心结构。在生物医学领域特别是药物输运上可能具有广阔的应用前景。
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| 关 键 词： | 四氧化三铁 葡聚糖 磁性微球 |
| 文章编号： | 1001-9731（2007）增刊-1957-04 |
| 修稿时间： | 2007-04-27 |
Preparation of Fe3O4/dextran magnetic microsphere and its potential application in drugs deliver |
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| JIANG Cui-feng, JIANG Wan-quan, HA Ling-yun, GNG Xing-long, CA Zhen, GU Rui.Preparation of Fe3O4/dextran magnetic microsphere and its potential application in drugs deliver[J].Journal of Functional Materials,2007,38(A05):1957-1960. |
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| Authors: | JIANG Cui-feng JIANG Wan-quan HA Ling-yun GNG Xing-long CA Zhen GU Rui |
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| Affiliation: | 1.Department of Chemistry, University of Science and Technology of China, Hefei 230026, China; 2.Department of Mechanics and Mechanical Engieering, University of Science and Technology of China, CAS Key Laboratory of Mechanical Behavior and Design of Materials,Hefei 230027, China; 3.Fuyang Normal College, Fuyang 236032, China |
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| Abstract: | An improved method of preparing magnetite-dextran microsphere is proposed. Several parameters were evaluated and the characteristics of the microspheres were investigated by XRD,TEM, FT-IRand TGA. The XRD results showed that the particles were indeed FeaO4. The transmission electron microscope images of the PSA@Fe3O4 exhibited that the nanoparticles with a diameter in the range of 30-100nm, the mean diameter is about 50nm.The resultant nanoparticles could be to have the capacity of encapsulation. |
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| Keywords: | magnetite-dextran mierosphere biocompatible |
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