| 一种新的标记配合物~(99m)TcN-tetrofosmin的制备及其动物分布的初步研究 |
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| 引用本文： | 陆洁,吕恭序,王学斌.一种新的标记配合物~(99m)TcN-tetrofosmin的制备及其动物分布的初步研究[J].核技术,2001(11). |
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| 作者姓名： | 陆洁 吕恭序 王学斌 |
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| 作者单位： | 北京师范大学化学系 北京100875
(陆洁，吕恭序)，北京师范大学化学系 北京100875(王学斌) |
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| 摘 要： | 在成功制备 99mTcN]2 + int 核中间体的基础上 ,通过配体交换反应制得放化纯度大于 95 %的99mTcN -tetrofosmin标记配合物。该配合物在制备后室温放置 6h、放化纯度基本不变 ;小鼠生物分布实验表明其在心肌有一定的摄取和较好的滞留 ,血、肺清除较快 ,有较高的心 /血和心 /肺比 ,心 /肝比值在注射后 2h可大于 1。
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| 关 键 词： | 心肌显像剂 Tetrofosmin 99mTcN-tetrofosmin 生物分布 |
The preparation and preliminary animal experiment of a new complex: ~(99m)TcN-tetrofosmin |
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| LU Jie,LU Gongxu,WANG Xuebing.The preparation and preliminary animal experiment of a new complex: ~(99m)TcN-tetrofosmin[J].Nuclear Techniques,2001(11). |
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| Authors: | LU Jie LU Gongxu WANG Xuebing |
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| Abstract: | On the basis of successfully obtained 99m TcN] 2+ int core, the complex 99m TcN-tetrofosmin was prepared through the ligand-exchange reaction. The radiochemical purity of 99m TcN-tetrofosmin was over 95% by TLC. A study of stability indicated the complex was stable over 6h at room temperature. The mice biodistribution of 99m TcN-tetrofosmin showed the accumulation in myocardium with high retention and rapid blood and lung clearance. |
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| Keywords: | Myocardial imaging agent Tetrofosmin 99m TcN-tetrofosmin Biodistribution |
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