Piezoelectric actuator: Searching inspiration in nature for osteoblast stimulation |
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Authors: | C Frias J Reis F Capela e Silva J Potes J Simões AT Marques |
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Affiliation: | 1. Departamento de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto (FEUP), Rua Roberto Frias s/n, 4200-465 Porto, Portugal;2. Departamento de Medicina Veterinária, Universidade de Évora, Pólo da Mitra, Ap. 94, 7002-554 Évora, Portugal;3. Institute of Agrarian and Environmental Mediterranean Sciences and Department of Biology, University of Évora, 7002-554 Évora, Portugal;4. Departamento de Mecânica, Universidade de Aveiro, Campus de Universitário de Santiago, s/n, 3810-193 Aveiro, Portugal |
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Abstract: | Bone is a composite with piezoelectric properties. Bone mass and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels, but the role piezoelectricity plays in bone physiology is yet to be understood. Physical activity enhances bone density, through mechanical stimulation. Osteocytes and osteoblasts are essential for mechanosensing and mechanotransduction. Strategies have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experimentally validate the use of piezoelectric materials as a mean of directly straining bone cells by converse piezoelectric effect. To estimate the magnitude of stress/strain, finite numerical models were applied and theoretical data was complemented by optic experimental data. Osteoblasts were then grown on the surface of the piezoelectric material and cell response studied. |
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Keywords: | A Smart material Polymeric piezoelectric C Finite element analysis (FEA) C Stress concentrations |
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