Preparation of fatty 3,5-disubstituted isoxazole compounds from FA esters |
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Authors: | James A Kenar Amanda R Wetzel |
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Affiliation: | (1) ARS, NCAUR, Food & Industry Oil Research, USDA, 1815 N. University St., 61604 Peoria, IL |
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Abstract: | Long-chain fatty compounds containing an isoxazole heterocyclic ring system substituted at the 3- and 5-ring positions were
prepared in moderate to good yields (40–64%) in one pot by condensing FA esters such as methyl palmitate, stearate, oleate,
or linoleate with the lithiated anion of N-(isopropylidene)isopropylamine followed by dehydrative cyclization. This approach allows readily available FA esters to be
utilized and incorporated into the construction of the isoxazole ring system. These novel products were isolated then characterized
by NMR, IR spectroscopy, GC-MS, and m.p. Mass spectra of the fatty isoxazole compounds, derived utilizing EI ionization, showed
distinctive cleavage patterns that occurred uniformly along the fatty alkyl chain allowing the position of double bonds to
be readily located. Two prominent ions at m/z 97 and 110 were common to all the fatty isoxazole compounds examined and were presumably from a McLafferty rearrangement
and a cyclization displacement reaction, respectively. |
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Keywords: | 3 5-Disubstituted isoxazoles FA esters imines lithiated imine anions mass spectrometry methyl linoleate methyl oleate methyl palmitate methyl stearate nuclear magnetic resonance |
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