| 黑果枸杞叶总黄酮的体外抗氧化活性研究 |
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| 引用本文： | 李 进,李淑珍,冯文娟,原 慧.黑果枸杞叶总黄酮的体外抗氧化活性研究[J].食品科学,2010,31(13):259-262. |
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| 作者姓名： | 李 进 李淑珍 冯文娟 原 慧 |
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| 作者单位： | 新疆师范大学生命科学与化学学院，新疆珍稀濒危物种保护生物学实验室 |
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| 基金项目： | 新疆维吾尔自治区科技支疆项目(200991240)；新疆师范大学重点实验室重大招标课题(ZXBW08-4) |
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| 摘 要： | 通过测定黑果枸杞叶总黄酮的还原能力，以及对小鼠血清羟自由基清除能力、小鼠红细胞溶血性、小鼠肝组织脂质过氧化产物MDA 生成的影响，探讨黑果枸杞总黄酮的体外抗氧化活性。结果表明：黑果枸杞总黄酮在化学本质上具有一定的抗氧化能力，能显著抑制小鼠红细胞溶血，IC50 为0.124mg/mL；能增强小鼠血清抗活性氧能力，抑制小鼠肝组织脂质过氧化产物MDA 生成，并显示出一定的量效关系。说明黑果枸杞叶总黄酮在一定浓度范围内具有抗氧化活性。
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| 关 键 词： | 黑果枸杞 黄酮 抗氧化 体外 |
| 收稿时间： | 2009-11-24 |
in vitro Antioxidant and Free Radical Scavenging Activities of Total Flavonoids from the Leaves of Lycium ruthenicum Murr. |
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| LI Jin,LI Shu-zhen,FENG Wen-juan,YUAN Hui.in vitro Antioxidant and Free Radical Scavenging Activities of Total Flavonoids from the Leaves of Lycium ruthenicum Murr.[J].Food Science,2010,31(13):259-262. |
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| Authors: | LI Jin LI Shu-zhen FENG Wen-juan YUAN Hui |
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| Affiliation: | Key Laboratory of Rare and Endangered Species Conservation Biology in Xinjiang, College of Life Science and Chemistry,
Xinjiang Normal University, Urumqi 830054, China |
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| Abstract: | In this study, the total flavonoid extract from the leaves of Lycium ruthenicum Murr. was tested for its reducing power, hydroxyl free radical scavenging activity, inhibitory effects on H2O2-induced hemolysis of mouse erythrocytes and on the generation of MDA, one of the end products of lipid peroxidation in hepatic tissue of mice in an effort to assess its in vitro antioxidant and free radical scavenging activities. The results indicated that the extract could significantly inhibit hemolysis of mouse erythrocytes with an IC50 of 0.124 mg/mL, enhance the tolerance to reactive oxygen species in mouse serum, and reduce MDA generation in hepatic tissue of mice in a dose-dependent manner. Hence, the extract is a promising free radical scavenger and antioxidant. |
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| Keywords: | Lycium ruthenicum Murr total flavonoids antioxidant activity in vitro |
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