乳铁蛋白免疫增强作用评价

根据我国免疫调节功能食品的评价方法，对乳铁蛋白的免疫调节作用进行评价。在实验中，采用Balb/c小鼠建立免疫低下模型，以不同剂量(100μg/mL、1mg/mL、10mg/mL)乳铁蛋白灌胃实验动物，分别进行免疫脏器质量、细胞免疫功能、体液免疫功能、单核- 巨噬细胞功能指标的检测。结果表明，在灌胃剂量为0.1～10mg/mL范围内，结果均为阳性，且以1mg/mL 最为显著。判定乳铁蛋白具有增强免疫力，但与剂量有关。

Evaluation on Immune-enhancement Effect of Lactoferrin

The immune regulatory function of lactoferrin was evaluated according to relevant Chinese national standards for evaluation of immune regulatory functional food. Balb/c mice were chosen to establish an immunodeficiency model. The immunodeficiency mice were orally administered lactoferrin at the dosages of 0.1, 1 mg/mL and 10 mg/mL, respectively. The effect of lactoferrin on immune organ weight, cellular immune function, humoral immune function and monocyte macrophages function were determined. The results showed that lactoferrin exhibited positive reaction within the dosage range of 0.1－10 mg/mL, and the strongest immune effect of lactoferrin was 1 mg/mL. Therefore, it can be concluded that lactoferrin exerts immune regulatory function in a dose-dependent manner.