| 药代研究中MAS法、蛋白沉淀法和固相萃取法等前处理方法的比较 |
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| 引用本文： | 李建旺,王宛,黄韦,冯俊雄,汪群杰. 药代研究中MAS法、蛋白沉淀法和固相萃取法等前处理方法的比较[J]. 质谱学报, 2009, 30(Z1): 128-130 |
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| 作者姓名： | 李建旺 王宛 黄韦 冯俊雄 汪群杰 |
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| 作者单位： | 1. 天津博纳艾杰尔科技有限公司，天津 300457；2. 中国农业科学研究院，北京 100081 |
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| 摘 要： |
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Comparison of MAS Pretreatment,Protein Precipitation and Solid Phase Extraction in DMPK |
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| LIJian-wang,WANGWan,HUANGWei,FENGJun-xiong,WANGQun-jie. Comparison of MAS Pretreatment,Protein Precipitation and Solid Phase Extraction in DMPK[J]. Journal of Chinese Mass Spectrometry Society, 2009, 30(Z1): 128-130 |
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| Authors: | LIJian-wang WANGWan HUANGWei FENGJun-xiong WANGQun-jie |
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| Affiliation: | 1. Tianjin Bonna-Agela Technologies, Tianjin 300457, China; 2. The Chinese Academy of Agricultural Sciences, Beijing 100081, China |
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| Abstract: | A new pretreatment method was introduced into DMPK(drug metabolism and pharmacokinetic) studies, which was named MAS(multi-function Impurity Adsorption SPE), ultilizing some special adsorbents to remove the impurities, such as phospholipid. It has a better performance compared to traditional protein precipitation and SPE pretreatment. Combined with LC/MS, MAS can be applied in DMPK as a high throughput and effective pretreatment successfully. |
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| Keywords: | DMPK MASpre-treatment LC/MS |
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