沙枣多糖抗疲劳作用及其机制的研究

目的：探讨沙枣多糖(EAP)的抗疲劳生物功效及其机制。方法：取健康雄性清洁级ICR 小鼠192 只，随机分为4 批，每批48 只，分别进行负重游泳、肝糖原测定、血清尿素氮和血乳酸测定实验。每批动物再随机分为4 组，即正常对照组、EAP 低剂量组(100mg/(kg bw·d))、EAP 中剂量组(500mg/(kg bw·d))、EAP 高剂量组(1000mg/(kg bw·d))，连续灌胃30d 后分别测定负重游泳时间、肝糖原含量、血清尿素氮和血乳酸含量。结果：EAP 中、高剂量组能延长小鼠负重游泳时间；EAP 各剂量组均能增加肝糖原含量；EAP 低、高剂量组能够减少血清尿素氮含量；EAP 中、高剂量组能降低血乳酸含量。结论：EAP 具有明显的抗疲劳作用。

Anti-fatigue Effect and Mechanism of Polysaccharides from Eleagnus angustifolius L.

Objective: To explore the anti-fatigue effect and mechanism of polysaccharides from Eleagnus angustifolius L. Methods: A total of 192 Kunming mice were randomly divided into 4 batches, each of which consisted of 4 groups: EAP groups at the dosages of low (100 mg/(kg bw·d)), middle (500 mg/(kg bw·d)) and high (1000 mg/(kg bw·d)) levels, and the control group. Each mouse was administered once a day for 30 days. After the end of the administration, all the mice were evaluated for their weight-loaded swimming duration and the contents of hepatic glycogen, blood urea nitrogen and blood lactic acid. Results: EAP at the high and middle dosages could prolong weight-loaded swimming duration, and decrease blood lactic acid level of mice. Hepatic glycogen content exhibited an increase in all groups administered EAP. In addition, a decline of blood urea nitrogen was observed in mice administered EAP at the high and low dosages. Conclusion: EAP could alleviate physical fatigue of mice.