| 牛乳铁素对几种免疫细胞因子的影响 |
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| 引用本文： | 胡志和,刘传国,李 娜,庞广昌,陈庆森.牛乳铁素对几种免疫细胞因子的影响[J].食品科学,2010,31(17):245-249. |
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| 作者姓名： | 胡志和 刘传国 李 娜 庞广昌 陈庆森 |
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| 作者单位： | 天津市食品生物技术重点实验室，天津商业大学生物技术与食品科学学院 |
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| 基金项目： | 天津市科技支撑计划重点项目(07ZCKFNC00200) |
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| 摘 要： | 通过对灌胃牛乳铁素(LfcinB)后小鼠血清中细胞因子IL-2、IL-4、IL-6、IL-10 和TNF-α水平的变化，评价其免疫调节作用。结果表明，灌胃牛乳铁素后3h 采血，分离其血清，用ELISA 试剂盒检测细胞因子，与阴性对照组相比，对细胞因子IL-2 和TNF- α产生极显著促进作用(P ≤ 0.01)，对抗炎细胞因子IL-4 有极显著的抑制作用(P ≤ 0.01)，对IL-6 有显著的抑制作用(P ≤ 0.05)，对抗炎细胞因子IL-10 的分泌影响也极显著(P ≤ 0.01)，并且IL-10 随TNF-α的增强而增强，起到平衡作用。因此，口服牛乳铁素对实验小鼠具有免疫增强和调节作用。
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| 关 键 词： | 牛乳铁素 细胞因子 免疫调节 |
| 收稿时间： | 2009-12-24 |
Effect of Bovine Lactoferricin on Cytokines |
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| HU Zhi-he,LIU Chuan-guo,LI Na,PANG Guang-chang,CHEN Qing-sen.Effect of Bovine Lactoferricin on Cytokines[J].Food Science,2010,31(17):245-249. |
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| Authors: | HU Zhi-he LIU Chuan-guo LI Na PANG Guang-chang CHEN Qing-sen |
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| Affiliation: | Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce,
Tianjin 300134, China |
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| Abstract: | In order to figure out whether bovine lactoferricin (LfcinB) has immuno-regulation function, cytokines such as IL-2, IL-4, IL-6, IL-10 and TNF-α in blood sera from mice orally administered with LfcinB were tested using ELISA kits. The results indicated that IL-2 and TNF-α levels in lactoferricin treatment mice at 3 h post-administration were both even higher (P ≤ 0.01) than those in negative control mice, whereas the levels of anti-inflammatory cytokines, IL-4 (P ≤ 0.01) and IL-6 (P ≤0.05) revealed a significant decrease, and IL-10 level which is positively correlated with TNF-α level and plays a balancing role also changed notably. Therefore, oral administration of lactoferricin has the potential to provide the function of immune enhancement and regulation. |
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| Keywords: | lactoferricin cytokine immuno-regulation function |
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