| 液相色谱-串联质谱法测定Beagle犬血浆中罗替戈汀的浓度 |
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| 引用本文： | 苏小函,沙春洁,刘万卉.液相色谱-串联质谱法测定Beagle犬血浆中罗替戈汀的浓度[J].质谱学报,2009,30(Z1):113-115. |
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| 作者姓名： | 苏小函 沙春洁 刘万卉 |
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| 作者单位： | 1. 烟台大学药学院，山东 烟台 264005；2. 山东绿叶制药有限公司，山东 烟台 264003 |
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| 摘 要： |
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Determination of Rotigotine in Beagle Dog Plasma by HPLC-MS/MS |
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| SUXiao-han,SHAChun-jie,LIUWan-hui.Determination of Rotigotine in Beagle Dog Plasma by HPLC-MS/MS[J].Journal of Chinese Mass Spectrometry Society,2009,30(Z1):113-115. |
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| Authors: | SUXiao-han SHAChun-jie LIUWan-hui |
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| Affiliation: | 1. School of Pharmacy, Yantai University, Yantai 264005, China; 2. Shandong Luye Pharmaceutical Co. Ltd, Yantai 264003, China |
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| Abstract: | The rotigotine in beagle dog plasma was determined by liquid chromatographic-tandem mass spectrometry. The method of HPLC-MS/MS was used, and detection was performed on a tandem spectrometry in multiple reaction monitoring(MRM) mode. The standard curves are linear in the range of 0.025-12.5 μg L－1, and the recovery is 89%-91%, the intra-day and the inter-day precision are less than 5.6% and 6.8%, respectively. The low limit of quantification(LLOQ) is 0.025 μg L－1. The specificity is good and sensitive, so this method is suitable for the parmacokinetical research of rotigotine. |
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| Keywords: | rotigotine HPLC-MS/MS plasmaconcentration |
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