降血脂功效成分体外筛选方法研究进展

高通量降血脂活性成分筛选为高脂血症治疗药物和保健品开发提供了便捷通道。本文从受体筛选模型、胆固醇代谢筛选模型、模拟胆汁胶束法和脂质代谢调控酶的抑制剂方面，对近年来国内外降血脂成分体外筛选方法进行了介绍，为降血脂活性成分的筛选研究提供参考。

Research Progress of Screening Methods for Hypolipidemic Components in vitro

Abnormal lipid metabolism is one of risk factors for atherosclerotic cardiovascular disease. The commonly used hypolipidemic drugs have toxicity to some extents. Screening effective, non-toxic, natural hypolipidemic ingredients has become one of hot topics in the fields of modern medicine, nutrition and biotechnology at home and abroad. Animal models with hyperlipidemia were high cost, time-consuming and unsuitable for high throughput screening. A convenient strategy for developing hypolipidemic drugs and health foods is to screen bioactive components in vitro. In this paper, screening methods for hypolipidemic drugs in vitro have been reviewed, which will provide references for further research of hypolipidemic components.