DART-MS在中国的应用研究现状

敞开式离子化质谱（ambient ionization mass spectrometry, AIMS）技术因其具有实时、原位分析等特点，已成为质谱学领域的一个研究热点。实时直接质谱分析（direct analysis in real-time mass spectrometry, DART-MS）作为一种典型的直接质谱分析技术，可在开放环境中实现样品的快速分析，具有性能稳定、操作简单、分析快速等优点，自2005年被报道以来，便引起了广泛的关注。本文从DART电离源的工作原理以及近2年DART-MS在环境分析、食品药品安全、生物医学分析以及公共安全等领域的应用研究进行了评述，并对其发展方向进行了展望。

Current Application Status of DART-MS in China

Ambient ionization mass spectrometry has become a hot area in the field of mass spectrometry due to its real-time and in situ analysis recently. As a typical kind of ambient ionization, direct analysis in real-time (DART) has attracted extensive attention since introduced in 2005. Great efforts have been applied in the research of the ionization mechanism and application of DART-MS. Penning ionization, proton transfer, electron capture and transient micro-environment mechanism have been reported involved in the DART ionization process. Due to its advantages of stability, operability, and analysis speed, DART-MS has been widely used in the environment monitoring, food and drug safety, biomedical analysis, and public security administration. Great achievement was inspiring, but several problems still remained, such as quantitative performance and direct analysis of analytes inside bulk sample. Therefore, in this paper, the mechanism of DART, the application of DART-MS in China were briefly summarized and discussed during the past two years, and the development tendency of DART-MS was prospected.