Various skin impedance models based on physiological stratification

Transdermal drug delivery is a non‐invasive method of drug administration. However, to achieve this, the drug has to pass through the complicated structure of the skin. The complex structure of skin can be modelled by an electrical equivalent circuit to calculate its impedance. In this work, the transfer function of three electrical models of the human skin (Montague, Tregear and Lykken Model) based on physiological stratification are analysed. Sensitivity analysis of these models is carried out to consider the extent to which changes in system parameters (different types of R and C as described by different models) affect the behaviour of the model. Techniques like normal of derivative and Hausdorff Distance is also used to study and understand the different curves. Comparison is also made with CPE based model. As Montague Model is the most widely used model, Tregear and Lykken Model are compared with it. It can be commented that out of the above observations Tregear Model at Level 3 can be used for establishing the electrical equivalent of human skin due to its simplicity. However, fractional ordered CPE models provide a good approximation. Future prospect lies in developing a model that characterize both biological properties and physiological stratification.Inspec keywords: electric impedance measurement, transfer functions, biological techniquesOther keywords: skin impedance models, physiological stratification, transdermal drug delivery, noninvasive method, drug administration, electrical equivalent circuit, electrical models, human skin, Lykken models, sensitivity analyses, Montague model, Tregear model, CPE models, constant phase element‐based model, Hausdorff distance