| 加替沙星合成工艺改进研究 |
| |
| 引用本文： | 李倩,赵世明,罗振福,孙有光.加替沙星合成工艺改进研究[J].精细化工中间体,2009,39(5):37-40. |
| |
| 作者姓名： | 李倩 赵世明 罗振福 孙有光 |
| |
| 作者单位： | 1. 天津理工大学化学与化工工程学院,天津,300384
2. 天津药物研究院化学制药研究部,天津,300193 |
| |
| 摘 要： | 以3，4，5，6-四氟苯二甲酸为起始原料，依次经水解、脱羧、甲基化、酰化、缩合、脱羧、丙胺酯、环合、硼酯化及缩哌反应得到加替沙星。总收率为18.3％（以3，4，5，6-四氟苯二甲酸计），并对合成工艺进行了优化，工艺适合于工业化生产。
|
| 关 键 词： | 3 4 5 6-四氟苯二甲酸 合成 优化 |
Process Imporvement of Synthesis of Gatifloxacin |
| |
| LI Qian,ZHAO Shi-ming,LUO Zhen-fu,SUN You-guang.Process Imporvement of Synthesis of Gatifloxacin[J].Fine Chemical Intermediates,2009,39(5):37-40. |
| |
| Authors: | LI Qian ZHAO Shi-ming LUO Zhen-fu SUN You-guang |
| |
| Affiliation: | LI Qian , ZHAO Shi-ming, LUO Zhen-fu, SUN You-guang(1. School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China; 2. Chemical Pharmaceuticals Department, Tianjin Pharmaceutical Research Institute, Tianjin 300193, China) |
| |
| Abstract: | Title compound was prepared starting from 3,4,5,6-tetrafluorophthalic acid via hydrolysis, decarboxylation, methylation, acylation, condensation, decarboxylation, propylamine esters, cyclization, boron esterification and condensation with piperazine in an overal yield of 18.3%. The reaction conditions were optimized, which are adaptable to industrial scale-up. |
| |
| Keywords: | 3 4 5 6-tetrafluorophthalic acid synthesis optimization |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
