Note: Integration of trapped ion mobility spectrometry with mass spectrometry |
| |
Authors: | Fernandez-Lima F A Kaplan D A Park M A |
| |
Affiliation: | Department of Chemistry, Texas A&M University, College Station, Texas 77843-3144, USA. ffernandez@chem.tamu.edu |
| |
Abstract: | The integration of a trapped ion mobility spectrometer (TIMS) with a mass spectrometer (MS) for complementary fast, gas-phase mobility separation prior to mass analysis (TIMS-MS) is described. The ion transmission and mobility separation are discussed as a function of the ion source condition, bath gas velocity, analysis scan speed, RF ion confinement, and downstream ion optical conditions. TIMS mobility resolution depends on the analysis scan speed and the bath gas velocity, with the unique advantage that the IMS separation can be easily tuned from high speed (~25 ms) for rapid analysis to slower scans for higher mobility resolution (R > 80). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|