Polyacrylamide-coated MCM-48 mesoporous silica spheres: synthesis,characterization and drug delivery study |
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| Authors: | H Iván Meléndez-Ortiz Bertha Puente-Urbina Erika Ibarra-Vallejo Lorena García-Uriostegui Alejandra Ortega |
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| Affiliation: | 1.CONACyT–Centro de Investigación en Química Aplicada,Saltillo,Mexico;2.Centro de Investigación en Química Aplicada,Saltillo,Mexico;3.Facultad de Ciencias Químicas,Universidad Autónoma de Coahuila,Saltillo,Mexico;4.CONACyT - Departamento de Madera Celulosa y Papel,Universidad de Guadalajara,Zapopan,Mexico;5.Instituto de Ciencias Nucleares,Universidad Nacional Autónoma de México,Mexico City,Mexico |
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| Abstract: | Mesoporous type-MCM-48 silica was grafted with polyacrylamide (PAAm) by using an azo-type initiator. The effect of monomer and initiator concentrations, reaction time, and temperature were evaluated to determine the optimal grafting conditions. Functionalized MCM-48 silicas were characterized by X-ray diffraction (XRD), infrared spectroscopy, thermogravimetric analysis, nitrogen adsorption–desorption analyses, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) which confirmed the grafting process. According to XRD, SEM and TEM results, PAAm-modified MCM-48 silica did not show changes in its morphology and mesostructure by comparing with pristine MCM-48. Also, modified silicas were tested as delivery system using nalidixic acid as drug model. MCM-48-PAAm silicas were able to load more significant amounts of nalidixic acid than the unmodified MCM-48, and showed a sustained delivery behaviour, releasing about 80% of drug. |
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