Preparation and characterization of artificial skin using chitosan and gelatin composites for potential biomedical application |
| |
Authors: | Shahed Parvez M. Mizanur Rahman Mubarak A. Khan M. Anwar H. Khan Jahid M. M. Islam Mostak Ahmed M. Fizur Rahman Belal Ahmed |
| |
Affiliation: | 1. Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, Bangladesh 2. Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh 3. Department of Chemistry, Shahjalal University of Science and Technology, Sylhet, Bangladesh 4. Department of Chemistry, Jagannath University, Dhaka, Bangladesh
|
| |
Abstract: | A bioadhesive wound-dressing material based on the combination of gelatin and chitosan with a proper ratio was developed and successfully applied in biomedical fields. The composite films were prepared with increase in chitosan concentration in a fixed amount of gelatin and were evaluated for mechanical stability (e.g., tensile strength, elongation-at-break), water and buffer uptake capacity, water and buffer aging, molecular structure, morphology, thermal stability, and for biological properties (e.g., antimicrobial activity, cytotoxicity, in vivo wound-healing performance). It is noteworthy that the 10:3 (gelatin:chitosan) composite films showed the best physico-mechanical, thermal, and antimicrobial properties among the other ratios blend films. The improved mechanical and thermal stability of the 10:3 composite film suggested its promising use as carrier for controlled release drug. The composite film was evaluated using a rat model for in vivo tests to ascertain the applicability of the proper ratio of the chitosan and gelatin in the film for best wound-healing activity. Wound sites dresses with gelatin/chitosan composite films showed excellent rapid healing of the wound surface than those dressed with eco-plaster and gauze. Within a day after dressing with 10:3 composite film, the healing efficiency was found to be 80?%. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|