Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytes |
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| Authors: | HH Kerschbaum MD Cahalan |
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| Affiliation: | Department of Animal Physiology, Institute of Zoology, University of Salzburg, A-5020 Salzburg, Austria. Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA. |
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| Abstract: | In T lymphocytes, a store-operated calcium ion (Ca2+) entry mechanism termed the calcium release-activated Ca2+ channel (CRAC channel) underlies the sustained or oscillatory intracellular calcium concentration signal required for interleukin-2 gene expression and cell proliferation. The use of sodium ions as a current carrier enabled single-channel recordings of CRAC channels during activation, inactivation, and blockade of current in the presence of divalent cations. A large conductance of 36 to 40 picosiemens indicates that 100 to 400 CRAC channels are present in T lymphocytes. |
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