| 肿瘤显像剂18F-氟代乙酸盐的自动化合成 |
| |
| 引用本文： | 唐刚华,唐小兰,王明芳,罗磊,甘满权.肿瘤显像剂18F-氟代乙酸盐的自动化合成[J].核技术,2006,29(1):59-62. |
| |
| 作者姓名： | 唐刚华 唐小兰 王明芳 罗磊 甘满权 |
| |
| 作者单位： | 1. 南方医科大学南方医院核医学科PET中心,广州,510515
2. 华南农业大学理学院,广州,510642 |
| |
| 基金项目： | 广东省科技厅科技计划
,
南方医科大学校科研和教改项目 |
| |
| 摘 要： | 为研究肿瘤显像剂18F-氟代乙酸盐(18F-FAC)的自动化合成工艺,采用"一锅法"和TRACERlab FXF-N自动化合成装置,以溴代乙酸苄酯为前体,在同一反应瓶中经亲核氟化、NaOH水解两步反应及HPLC系统分离纯化制备18F-FAC注射液.总合成时间约50 min,未校正放化产率和放化纯度分别大于45%和99%.采用"一锅法"自动化合成18F-FAC,操作简便,能满足科研和临床正电子发射断层显像的需要.
|
| 关 键 词： | 18F-氟代乙酸盐 肿瘤显像剂 自动化合成 |
| 收稿时间： | 12 2 2004 12:00AM |
| 修稿时间： | 2004-12-022005-03-10 |
Automated synthesis of 18 F-fluoroacetate as tumor imaging agent |
| |
| TANG Ganghua,TANG Xiaolan,WANG Mingfang,LUO Lei,GAN Manquan.Automated synthesis of 18 F-fluoroacetate as tumor imaging agent[J].Nuclear Techniques,2006,29(1):59-62. |
| |
| Authors: | TANG Ganghua TANG Xiaolan WANG Mingfang LUO Lei GAN Manquan |
| |
| Affiliation: | 1.PET Centre, Department of Nuclear Medicine, Nan Fang Hospital, Southern Medical University, Guangzhou 510515;2.College of Science, South China Agricultural University, Guangzhou 510642 |
| |
| Abstract: | To improve the automated synthesis technology of 18F-fluoroacetate (18F-FAC) as tumor imaging agent, the one-pot procedure at TRACERlab FXF-N module was tried. 18F-FAC injection was obtained via a two-step reaction including nucleophilic fluorination of the precursor benzyl bromoacetate with 18F-fluoride and subsequent hydrolysis of the protecting group with 3 mol/L NaOH at the same reaction vessel, and purification with HPLC system. 18F-FAC was automatically synthesized with an uncorrected radiochemical yield of more than 45% and radiochemical purity of more than 99% in the synthesis process of about 50 min. 18F-FAC injection is easy to be obtained and can be used for clinical and scientific study with positron emission tomography (PET) imaging. |
| |
| Keywords: | ^18F-fluoroacetate Tumor imaging agent Automated synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
