C_(22)-三元酸的合成

以棉籽油脂肪酸为原料,将非共轭的亚油酸在碘催化下转化成共轭亚油酸,同时与富马酸发生Diels- Alder反应,制备了C_(22)-三元酸。采用正交实验设计探讨了投料比、温度、催化剂用量、反应时间对合成反应的影响。最佳合成条件为：n(富马酸)：n(亚油酸)=(1．1～1．2)：1,反应温度180～190℃,碘的用量(与棉籽油脂肪酸质量比)0．15%～0．2%,反应时间2～3h；亚油酸转化率为98%。

SYNTHESIS OF C22-CARBOXYLIC ACID

C_(22)-Tricarboxylic acid was synthesized from the fatty acid of cottonseed oil by converting non-conjugated linoleic acid to conjugated linoleic acid in the presence of iodine as catalyst,followed by Diels-Alder reaction between conjugated linoleic acid and fumaric acid.Orthogonal design was a- dopted to guide the experiments to study the influences of the ratios of reactants,reaction tempera- ture,amount of catalyst and reaction time on the reaction.The optimal conditions were obtained as follows:mole ratio of fumaric acid to linoleic acid (1.1-1.2):1,reaction temperature 180-190℃, reaction time 2-3 h,amount of iodine 0.15%-0.2% of the fatty acid of cottonseed oil.Under these conditions,the conversion of the linoleic acid was 98%.