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Optical and magnetic resonance imaging of cell death and platelet activation using annexin a5-functionalized quantum dots |
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| Authors: | Prinzen Lenneke Miserus Robbert-Jan J H M Dirksen Anouk Hackeng Tilman M Deckers Niko Bitsch Nicole J Megens Remco T A Douma Kim Heemskerk Johan W Kooi M Eline Frederik Peter M Slaaf Dick W van Zandvoort Marc A M J Reutelingsperger Chris P M |
| Affiliation: | Department of Biophysics, University of Maastricht, and Department of Radiology, University Hospital Maastricht, The Netherlands. L.Prinzen@bf.unimaas.nl |
| Abstract: | A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies. |
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