Cationic comb-type copolymers for boosting DNA-fueled nanomachines |
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Authors: | Choi Sung Won Makita Naoki Inoue Satoru Lesoil Charles Yamayoshi Asako Kano Arihiro Akaike Toshihiro Maruyama Atsushi |
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Affiliation: | Institute for Materials Chemistry and Engineering, Kyushu University, 6-10-1 Hakozaki, Higashi, Fukuoka 812-8581, Japan. |
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Abstract: | For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(l-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration. |
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