| 多囊卵巢综合征的胰岛素抵抗特征及相关因素研究 |
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| 引用本文： | 邱华娟,刘惠芬,纪燕琴. 多囊卵巢综合征的胰岛素抵抗特征及相关因素研究[J]. 化工之友, 2010, 0(6) |
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| 作者姓名： | 邱华娟 刘惠芬 纪燕琴 |
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| 作者单位： | 广东省惠州市中心人民医院妇科; |
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| 摘 要： | 目的探讨多囊卵巢综合征患者的胰岛素抵抗特点及与体重指数的关系。方法对2005年7月至2008年7月46例多囊卵巢综合征患者与26例健康女性进行比较研究。按体重指数分为非肥胖组和肥胖组。观察内分泌激素水平、体重指数、OGTT试验及胰岛素释放、稳态模式胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA IR等情况。结果肥胖与非肥胖PCOS组在内分泌激素FSH、PRL及E2等方面无明显差异,肥胖PCOS组LH水平(14.12±0.13)较非肥胖PCOS组(15.34±0.56)低(P<0.01),而T水平(4.21±0.87)较非肥胖PCOS组(3.61±0.78)高(P<0.01)。PCOS组空腹及OGTT2h后血糖及胰岛素水平均较对照组高(P<0.01),肥胖组较非肥胖组高(P<0.01)。PCOS组BMI与HOMA IR之间呈正相关,相关系数为r=0.67(P<0.01)。结论胰岛紊抵抗是多囊卵巢综合征患者代谢异常的基本特征,肥胖是引起胰岛素抵抗、多囊卵巢综合征的危险因素之一。
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| 关 键 词： | 多囊卵巢综合征 胰岛素抵抗 肥胖 |
Research of Insulin resistance and Its Relative Factors of Polycystic Ovarian Syndrome (PCOS) |
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| Abstract: | Objective To explore the characteristics of insulin resistance(IR)and its relationship with body mass index(BMI)in PCOS.Methods 46 patients with PCOS at our hospital between Jun,2005 and Jun,2008 were compared with 26 healthy women. According to body mass index(BMI),they were divided into fatty group and non-fatty group.Comparisons were conducted in the endocrinic hormone,BMI,OGTT test,insulin release and homeostasis model assessment of insulin resistance(HOMA IR).Results No significant differences were obs... |
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| Keywords: | Polycystic ovarian syndrome Insulin resistance Obesity |
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