Effect of chitosan multilayers encapsulation on controlled release performance of drug-loaded superparamagnetic alginate nanoparticles |
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| Authors: | Chunyin Lu Peng Liu |
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| Affiliation: | (1) State Key Laboratory of Applied Organic Chemistry and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China; |
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| Abstract: | The near monodispersed ibuprofen-loaded superparamagnetic alginate (AL/IBU/Fe3O4) nanoparticles with particles size less than 200 nm were prepared via the facile heterogeneous coprecipitation of the superparamagnetic
Fe3O4 nanoparticles, sodium alginate (AL) and the model drug ibuprofen (IBU) from the aqueous dispersion. Then the chitosan multilayers
were self-assembled onto the AL/IBU/Fe3O4 nanoparticles to produce novel magnetic-targeted controlled release drug delivery system, with chitosan as the polycation
(CS) and the carboxymethyl chitosan (CMCS) as the polyanion. The drug controlled releasing behaviors of the AL/IBU/Fe3O4 nanoparticles and the CS multilayers encapsulated ibuprofen-loaded superparamagnetic alginate ((AL/IBU/Fe3O4)@(CS–CMCS)3) nanoparticles were compared in the different pH media. In media with the same pH value, the encapsulated vessels exhibited
the slower releasing rate. |
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