| 流动相pH值对地西泮、艾司唑仑、氯氮卓、三唑仑HPLC色谱行为的影响 |
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| 引用本文： | 王蔚昕,张春水,黄星.流动相pH值对地西泮、艾司唑仑、氯氮卓、三唑仑HPLC色谱行为的影响[J].化学工程师,2011(8):26-28. |
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| 作者姓名： | 王蔚昕 张春水 黄星 |
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| 作者单位： | 公安部物证鉴定中心,北京,100038 |
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| 基金项目： | 基本科研业务费专项资金重点项目(2009JBGG001) |
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| 摘 要： | 在其它HPLC分析条件不变的前提下,本实验考察了地西泮、艾司唑仑、氯氮卓、三唑仑4种苯二氮卓类药物保留时间、拖尾因子、峰面积3个指标随流动相水相PH值改变而变化的趋势,初步总结了流动相pH值对4种药物HPLC色谱行为的影响.
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| 关 键 词： | 地西泮 艾司唑仑 氯氮卓 三唑仑 流动相pH值 HPLC色谱行为 |
Impact of pH value on the chromatography behavior of four kinds of Benzodiazepines by HPLC |
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| WANG Wei-xi,ZHANG Chun-shui,HUANG Xing.Impact of pH value on the chromatography behavior of four kinds of Benzodiazepines by HPLC[J].Chemical Engineer,2011(8):26-28. |
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| Authors: | WANG Wei-xi ZHANG Chun-shui HUANG Xing |
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| Affiliation: | WANG Wei-xi,ZHANG Chun-shui,HUANG Xing(Institute of Feremsic Science Ministry of Public Security,Beijing 100038,China) |
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| Abstract: | Fixing other parameters,the change of the diazepam,Estazolam,Chlordiazepoxide and triazolam in retention time,tailing factor and peak area with PH value were studied in reversed phase high performance liquid chromatography.And the impact of PH value on the chromatography behavior of the four drugs was summarized preliminarily. |
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| Keywords: | diazepam estazolam chlordiazepoxide triazolam pH value of liquid phase HPLC chromatography behavior |
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