| 生物材料聚(乳酸-天冬酰胺)的制备与表征 |
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| 引用本文： | 叶瑞荣,罗时荷,汪朝阳,谭越河. 生物材料聚(乳酸-天冬酰胺)的制备与表征[J]. 高分子材料科学与工程, 2011, 0(5): 141-144 |
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| 作者姓名： | 叶瑞荣 罗时荷 汪朝阳 谭越河 |
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| 作者单位： | 华南师范大学化学与环境学院 |
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| 基金项目： | 广东省自然科学基金资助项目(5300082);国家自然科学基金资助项目(20772035) |
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| 摘 要： | 以氯化亚锡为催化剂,L-乳酸(LA)与天冬酰胺(Asn)直接熔融聚合,所得生物材料聚(乳酸-天冬酰胺)[P(LA-co-Asn)]用[η]、红外光谱(FT-IR)、核磁共振(<'1>H-NMR)、凝胶渗透色谱(GPC)、差示扫描量热分析(DSC)、X射线衍射(XRD)等方法进行表征.随着投料比中Asn增加,共聚物由结晶...
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| 关 键 词： | 乳酸 天冬酰胺 聚(乳酸-co-天冬酰胺) 熔融聚合 生物医学材料 |
Synthesis and Characterization of Biomaterial Poly(Lactic Acid-co-Asparagine) |
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| Ruirong Ye,Shihe Luo,Zhaoyang Wang,Yuehe Tan. Synthesis and Characterization of Biomaterial Poly(Lactic Acid-co-Asparagine)[J]. Polymer Materials Science & Engineering, 2011, 0(5): 141-144 |
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| Authors: | Ruirong Ye Shihe Luo Zhaoyang Wang Yuehe Tan |
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| Affiliation: | Department of Chemistry,School of Chemistry and Environment,South China Normal University,Guangzhou 510006,China) |
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| Abstract: | Catalyzed by SnCl2,a novel biomaterial poly(lactic acid-co-asparagine)[P(LA-co-Asn)] was directly synthesized via the melt copolycondensation of L-lactic acid(LA) and asparagine(Asn).The copolymer was systematically characterized with intrinsic viscosity [η],FT-IR,1H-NMR,GPC,DSC and XRD measurements.Increasing the Asn content in the feed,w of the copolymer gradually became smaller,and the crystallinity gradually disappeared.P(LA-co-Asn) with w from 9,500 to 2,700 were obtained,which could meet the demand of drug delivery carrier material.The novel direct copolycondensation method was cheap and practical.Compared with the branched poly(lactic acid-co-aspartic acid),the pendent primary amide groups in the side chain of the novel linear copolymer P(LA-co-Asn) may be further modified by bioactive molecules,which will be more beneficial to improve biocompatibility of polylactic acid(PLA). |
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| Keywords: | lactic acid asparagine poly(lactic acid-co-asparagine) melt polycondensation biomedical materials |
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