琼脂糖的疏水化改性及生物相容性

采用乙酸酐对琼脂糖进行疏水性改性,合成了具有生物活性的琼脂糖醋酸酯.通过红外光谱(FT-IR)、13C核磁共振(13C-NMR)、原子力显微镜和接触角仪对琼脂糖醋酸酯进行了表征.结果表明,琼脂糖C6上引入了乙酰基,随取代度增大,琼脂糖醋酸酯膜表面粗糙度增大,疏水性增强.纺成丝后在水中不溶胀,形态保持完好,吸湿率最小可达...

Hydrophobic Modification of Agarose and Its Biocompatibility

A bioactive agarose acetate was prepared via the hydrophobic modification of acetic anhydride on agarose.Fourier transform infrared spectrum(FT-IR),13C nuclear magnetic resonance spectrum(13C-NMR),atom force microscope and contact angle were applied to the characterization of agarose acetate.The results indicate that acetyl groups are introduced into C6 of agarose and the roughness rate of agarose acetate membrane increases with higher substitution degree.The agarose acetate has the spinnability,and the fiber is not swelled,and their adsorbing rates of water can reach the minimum value,52.5%.The agarose acetate was prone to adsorb BSA protein,and fibroblasts adhered and proliferated on agarose acetate membrane very well.These findings prove that the agarose acetate is hopeful to be used as the tissue engineering scaffold.