The Radiation Chemistry of Cytochrome c |
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Authors: | W H Koppenol J Butler |
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Affiliation: | 1. Department of Chemistry, University of Maryland Baltimore County, Catonsville, MD 21228 USA;2. Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UK |
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Abstract: | The literature on the reaction of cytochrome c with the radiolytically generated radicals \documentclass{article}\pagestyle{empty}\begin{document}$ {\rm e}_{{\rm eq}}^ -,^. {\rm OH,}^{\rm .} {\rm H,CO}_2^ -,{\rm O}_{\rm 2}^ -,{\rm Br}_{\rm 2}^ - $\end{document} and various organic radicals is reviewed. It would appear that negatively charged radicals, aided by the electric field of cytochrome c, react at the exposed haem edge. Uncharged organic radicals also react at this site. \documentclass{article}\pagestyle{empty}\begin{document}$ ^. {\rm H} $\end{document} and \documentclass{article}\pagestyle{empty}\begin{document}$ ^. {\rm OH} $\end{document} are likely to reduce the prosthetic group indirectly by a tunnelling mechanism. |
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